8/19/2023 0 Comments Stem cell denverUnlike embryonic stem cells which are pluripotent, cord blood stem cells are multipotent. Endothelial progenitor cells and multipotent unrestricted adult stem cells can also be found in cord blood. Some non-hematopoietic stem cell types are also present in cord blood, for example, mesenchymal stem cells, however these are present in much lower numbers than what can be found in adult bone marrow. However, the interest in cord blood is mostly driven by the observation that cord blood also contains various types of stem and progenitor cells, mostly hematopoietic stem cells. Compared to whole blood some differences in the blood composition exist, for example, cord blood contains higher numbers of natural killer cells, lower absolute number of T-cells and a higher proportion of immature T-cells. There is growing interest from cell therapeutics companies in developing genetically modified allogenic natural killer cells from umbilical cord blood as an alternative to CAR T cell therapies for rare diseases.Ĭord blood is composed of all the elements found in whole blood – red blood cells, white blood cells, plasma, platelets. Cord blood is collected because it contains stem cells, which can be used to treat hematopoietic and genetic disorders such as cancer. Cord blood ( umbilical cord blood) is blood that remains in the placenta and in the attached umbilical cord after childbirth.
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